While running as an independent candidate, Manicad will have the backing of Sara Duterte's Hugpong ng Pagbabago party.
An ambitious old-school talk show that puts together all the heads of the MVP media properties in one table.
In a statement, the Kapuso anchor said he is currently being treated for kidney disease and will also undergo a heart bypass surgery in mid-September.
Mayrina replaces former newsman Jiggy Manicad.
The anchor swap will be just among the changes at the local CNN station this third quarter of 2018.