Ho opted not to renew her contract with the MVP media company as she takes a sabbatical from television.
Drilon is the latest big-name hire at the Cignal news channel.
This round of layoffs will impact all TV production and news production employees, with changes taking effect by the end of this week.
'Saksi' will now be solo anchored by Pia Arcangel, while Atom Araullo will now anchor 'State of the Nation' alone.
The 'Sa Totoo Lang' co-host has been promoted as officer-in-charge of Cignal’s news content.