In a statement, the Kapuso anchor said he is currently being treated for kidney disease and will also undergo a heart bypass surgery in mid-September.
Mayrina replaces former newsman Jiggy Manicad.
The anchor swap will be just among the changes at the local CNN station this third quarter of 2018.
The Kapamilya news channel's coverage, which lasted for more than 17 hours, was seen as the "most consistent” among the networks.
The veteran journalist talks about his new assignment as the executive producer 'The Chiefs'
MEWCY's new redesigned set in its new home base features "a huge LED wall, interactive touch screen and augmented reality setup."
Hosted by its resident business analyst Michael Alimurung, the program will have its initial telecast on July 6 at 4:30PM.
The Kapatid news chief was welcomed back with a new promotional video highlighting some of her most memorable work at the network.
Speaking exclusively to CNN Philippines' 'The Source,' the Ombudsman said she is looking forward to her retirement.
The state-run TV network also introduced Catherine Vital as Santos' co-anchor.