His exit comes amid a larger shakeup in the management ranks at CNN Philippines.
His retirement takes effect September 30.
The international, award-winning journalist will become anchor and managing editor at ANC.
Leading the pack is longtime TV5 host Shawn Yao, who will be anchoring the network's top of the hour news bulletin.
He will be responsible for the editorial direction, as well as all aspects of the channel's news programming and operations.
Pangilinan and other top TV5 bosses are finalizing a deal with the Bloomberg group to form a localized business news channel.
Francisco will stay with the Kapatid Network in his current anchor capacity and will continue to report nightly on 'Aksyon Tonite.'
Earlier this month, TV5 named veteran newsman Ed Lingao as the newscast's new co-anchor.
GMA News will also unveil new roles for Connie Sison and Pia Arcangel beginning November 10.
The "Reyna ng Kalsada" talks about her life and career as a journalist, her experience covering Yolanda... and everything!